Anti-VEGF therapies in many patients with wet age-related macular degeneration go on to develop atrophy. The speculation for causes of this are:
- Natural progression of underlying age-related macular degeneration driving the atrophy.
- Atrophy is associated with choroidal neovascularization.
- Atrophy is associated with anti-VEGF therapy independent of choroidal neovascularization.
No answers to these theories are yet available, so we should not change how we treat patients. We should, however, advise patients that treating wet age-related macular degeneration may not stop the progression of their underlying dry age-related macular degeneration.Page