Acute Zonal Occult Outer Retinopathy

Acute zonal occult retinopathy is a rare disorder known as AZOOR that is characterized by:

  1. acute loss of one or more zones of outer retinal function,
  2. minimal or no fundus changes initially,
  3. electroretinographic abnormalities, and
  4. permanent visual field loss.

Gass has broadened his definition of AZOOR to include Multiple Evanescent White-Dot Syndrome (MEWDS), acute macular neuroretinopathy, multifocal choroiditis, punctate inner choroidopathy. It is not known to what degree they are related pathogenetically or etiologically.

The cause is unknown. There is no evidence to date for autoantibodies to any retinal cell type. It primarily affects young adult women.

Vision loss can reverse itself from 20/400 to 20/20 with treatment of Prednisone, Acyclovir, and Doxycycline.