Individualized treat and extend TREX-DME trial for DME resulted in significantly fewer injections and yielded visual and anatomic gains comparable to monthly dosing at 2 years.
Decreasing the treatment burden while providing clinically significant visual and anatomic improvements is of paramount importance.
“Randomized Trial of Treat and Extend Ranibizumab With and Without Navigated Laser Versus Monthly Dosing for Diabetic Macular Edema: TREX-DME 2-Year Outcomes”
Am. J. Ophthalmol 202:91-99, June 2019
John F. Payne, Charles C. Wykoff, W. Lloyd Clark, Beau B. Bruce, David S. Boyer, and David M. Brown, For the TREX-DME Study Group